PyRosetta Packer Task Operations

from pyrosetta.rosetta.core.pack.task.operation import *

Prevent residues from repacking/designing

# PreventRepackingRLT()
my_task_factory.push_back(PreventRepackingRLT())

Allowing repacking, but disallowing designing

# RestrictToRepackingRLT()
my_task_factory.push_back(RestrictToRepackingRLT())

Operate on selected residues

See PyRosetta Selectors

Note | PyRosetta Selectors

no_packing_non_interface = OperateOnResidueSubset(PreventRepackingRLT(), not_interface_selector)
# Push it back to a TaskFactory object just like any other operations
my_task_factory.push_back( no_packing_non_interface )

Restrict design to user-specified residue

Restrict design to user-specified residues. If resnum is left as 0, the restriction will apply throughout the pose.

# Enable design on chain_A
aa_to_design = pyrosetta.rosetta.core.pack.task.operation.RestrictAbsentCanonicalAASRLT()
aa_to_design.aas_to_keep("ACDEFGHIKLMNPQRSTVWY")
tf.push_back(pyrosetta.rosetta.core.pack.task.operation.OperateOnResidueSubset(
    aa_to_design, chain_A))